Abstract
The synthesis and structure-activity relationships of a novel series of piperazine derivatives as dual inhibitors of serotonin and noradrenaline reuptake is described. Two compounds possessed comparable in vitro profiles to the dual reuptake inhibitor duloxetine.
MeSH terms
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Amines / chemistry
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Chemistry, Pharmaceutical / methods
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Drug Design
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Duloxetine Hydrochloride
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Humans
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Models, Chemical
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Norepinephrine / chemistry*
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Piperazines / chemistry*
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Selective Serotonin Reuptake Inhibitors / chemistry
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Selective Serotonin Reuptake Inhibitors / pharmacology*
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Serotonin / chemistry*
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Serotonin Plasma Membrane Transport Proteins / chemistry
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Structure-Activity Relationship
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Thiophenes / pharmacology
Substances
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Amines
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Piperazines
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Serotonin Plasma Membrane Transport Proteins
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Serotonin Uptake Inhibitors
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Thiophenes
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Serotonin
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Duloxetine Hydrochloride
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Norepinephrine